NIH R01 · 2024
Mechanisms and consequences of impaired glutathione homeostasis in the aging lens
Abstract The integrity of the lipid and cholesterol-enriched lens membrane is vital to lens homeostasis, stiffness, and transparency, serving as an impermeable barrier to cations and scaffold for major lens membrane proteins, such as aquaporin 0 (AQP0) and ion pump. Aging is a primary risk factor for cataractogenesis and presbyopia, and it drives a significant degree of lens membrane lipids compositional changes, such as the decline of unsaturated glycerophospholipids and the steady increase of more saturated sphingomyelin lipids. The steep decline of highly unsaturated glycerophospholipids in the lens is believed to result from selective lipid peroxidation, closely associated with lens…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.