NIH R01 · 2024
The Role of Pericytes in Brain Hypoperfusion in Alzheimer's Disease Development
PROJECT SUMMARY/ABSTRACT Vascular dysfunction, such as decreases in cerebral blood flow (CBF) and disruption of the blood brain barrier (BBB) are early symptoms of Alzheimer’s disease (AD) and could contribute to AD onset and progression. In the brain, specialized cells called pericytes are integral to proper vascular function, as they play a major role in regulating CBF and maintaining BBB integrity. However, the processes that govern pericyte dysfunction and the role of pericytes in decreases of CBF in AD development have not been fully elucidated. Our previous studies have demonstrated that increases in the transcription factor Fli-1 are associated with pericyte dysfunction and viability…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.