NIH R01 · 2025
How cerebrospinal fluid (CSF) potassium supports brain development and activity
PROJECT SUMMARY/ ABSTRACT The brain and spinal cord are filled with and surrounded by a complex fluid, the cerebrospinal fluid (CSF). CSF directly contacts brain progenitors to act as a stem cell niche that provides buoyancy, ionic and osmotic balance, and health- and growth- promoting factors. Pathological deviations in CSF volume and composition are associated with congenital, neuropsychiatric, infectious, and geriatric diseases, as well as injury. As the brain matures during development, CSF composition changes profoundly. We recently discovered that CSF ion concentrations also change dramatically across development, including a ~2.5-fold drop in CSF [K+] during the first postnatal week…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.