NIH R01 · 2025
Membrane-cytoskeleton interactions in megakaryocytes and platelets
PROJECT ABSTRACT Abnormal platelet production and function, due to genetic factors, cancer therapy, or unknown causes, pose significant clinical risks, including bleeding and thrombotic events. Platelets are produced primarily in the bone marrow by megakaryocytes through intricate processes involving polyploidization and extensive membrane and cytoskeletal rearrangements. These include the formation of the demarcation membrane system (DMS), the surface-connected membrane reservoir necessary for proplatelet extension and release within bone marrow sinusoids. Megakaryocytes also form podosomes, which serve as mechanosensing structures to identify the most conducive sites for initiating…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.