Falcone Lab

Research focus

NIH R01 · 2025

Anticoagulation in Intracerebral Hemorrhage Survivors with Atrial Fibrillation and Imaging Features of Cerebral Amyloid Angiopathy and Small Vessel Disease

PROJECT SUMMARY Non-traumatic intracerebral hemorrhage (ICH) is a devasting type of stroke caused by cerebral small vessel disease (CSVD). One-fourth of ICH patients have atrial fibrillation (AF), an important risk factor for ischemic stroke. Although anticoagulation therapy alleviates the risk of ischemic stroke in patients with AF, it can increase the risk of ICH. Observational data including our own, indicate that among ICH survivors, CSVD features such as microbleeds and white matter hyperintensities independently increase the risk of ischemic stroke, recurrent ICH, and poor functional outcomes. Whether CSVD similarly influences the net clinical benefit of anticoagulation in ICH…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.