NIH R01 · 2025
JAK1/2 as a Central Regulator of iMCD Pathogenesis and Novel Therapeutic Target
Project Summary/Abstract: Human herpesvirus(HHV)-8-negative, idiopathic multicentric Castleman disease (iMCD) is a deadly hematologic illness involving polyclonal lymphoproliferation and multiple organ system dysfunction. iMCD is diagnosed in approximately 1,500 individuals annually in the USA; 35% die within 5 years. Limited options exist beyond cytotoxic chemotherapies for the 66% of patients refractory to interleukin-6 (IL-6) blockade with siltuximab; relapse is common. The etiology, pathological cell types, and dysregulated signaling pathways are poorly understood. Improved understanding of disease mechanisms is necessary to identify new treatments. In the previous funding cycle, we…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.