Amiel Lab

Research focus

NIH R01 · 2024

Durable Schistosome induced metabolic alterations to the myeloid lineage

PROJECT SUMMARY Diabetic patients have a two-fold greater risk of developing cardiovascular disease than non-diabetic subjects, and more than 65% of diabetic patients die from cardiovascular complications, thus, there is a critical need for novel approaches to targeting insulin resistance, obesity, and atherosclerosis in this population. Recent evidence has suggested that innate and/or adaptive inflammatory responses are associated with both insulin resistance and obesity, while atherosclerosis is now widely accepted to be a lipid-dependent chronic inflammatory disease. An increasing body of literature has established an inverse correlation between chronic helminth infections and metabolic…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.