Dosenbach Lab

University of Minnesota

PEDIATRICS

Minneapolis · United States

NIH-funded
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Research focus

NIH R01 · 2024

Identification of outcome-based sub-populations using deep phenotyping and precision functional mapping across ADHD and ASD

Project Summary Two of the earliest onset, most common, and costly neurodevelopmental disorders in child psychiatry are Attention Deficit Hyperactivity Disorder (ADHD) and Autism spectrum disorders (ASD). The clinical heterogeneity and the imprecise nature of their nosological distinctions represents a fundamentally confounding factor limiting a better understanding of their etiology, prevention, and treatment. In short, simple design assumptions regarding `homogeneity in samples' in typical and atypical populations may explain the frequently very small effect sizes in psychopathology research. Clinically, these same assumptions may account for why treatments often have weak or…

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