Fahy Lab

Research focus

NIH R01 · 2025

Evaluating the Impact of Metabolic Dysfunction on Asthma Pathology and Physiology

Project Summary/Abstract: More than 40% of adult Americans are obese and obesity is common among patients with severe asthma. The mechanisms underlying the association between obesity and severe asthma are poorly understood, but a clue comes from the metabolic consequences of obesity, which include insulin resistance and systemic interleukin-6 inflammation. We recently showed that a subset of obese asthma patients have metabolic dysfunction (MD) and that obese patients with MD have more severe asthma than obese patients without MD. In addition, we found that lower lung function in obesity is more strongly related to measures of MD than measures of body mass index. Furthermore, we found that…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.