NIH R01 · 2025
Project Summary The existence of asymptomatic precursor lesions that are known to predate invasive pancreatic ductal adenocarcinoma (PDAC) by years provides a compelling “window of opportunity” for cancer interception efforts. One such precursor is intraductal papillary mucinous neoplasm (IPMN). Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) imaging of metabolites in tissue sections from resected patient IPMN cases and from a KrasG12D/GnasR201C mouse model of IPMN, we have made a discovery in identifying long chain hydroxylated sulfatide species that are selectively enriched in IPMN. Targeting of sulfatide metabolism via small molecule inhibition of ceramide…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.