NIH R01 · 2025
Hypocretin/orexin modulation of cognitive correlates of brain aging
The primary neurotransmitter hallmark of Alzheimer’s Disease (AD) is a loss of acetylcholine, produced by neurons of the basal forebrain cholinergic system (BFCS). Cholinergic cell loss or dysfunction is also a prominent component of Lewy Body Dementia and vascular dementia, respectively. Thus the BFCS contributes to several aspects of cognitive function that are negatively impacted in AD and related dementias, including attention, learning and memory. Regulation of the BFCS by afferent inputs, including those from the hypothalamus, is important for integration of homeostatic and cognitive functions. Because homeostatic and physiological disturbances, such as altered food intake or…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.