Faddegon Lab

Research focus

NIH R01 · 2025

Ionization Detail - Biologically based treatment planning for particle therapy beyond LET-RBE

Project Summary Current proton and ion therapy treatment planning procedures utilize either the physical quantity linear energy transfer (LET) as a surrogate for biological effectiveness or make use of relative biological effectiveness (RBE) models that convert absorbed dose to biologically weighted dose, assumed to be iso- effective to photons. LET is indeed important clinically for planning treatments with charged particles, but there are known problems. Ion beams with the same LET can have different RBE, depending on particle type and energy. Therefore, LET by itself is not an ideal parameter to use in radiation treatment planning (RTP). For clinical application of carbon therapy,…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.