Fabiilli Lab

Research focus

NIH R01 · 2024

Angiogenic growth factor delivery for vascular regeneration in critical limb ischemia using acoustically-responsive scaffolds

ABSTRACT The development of techniques to generate functional, perfused blood vessel networks is essential for engineering of viable tissues as well as for the treatment of ischemic diseases. Pro-angiogenic growth factors have been used, either as a standalone therapy or in combination with cell-based techniques, to promote vascularization. Unfortunately, conventional approaches for delivery of pro-angiogenic growth factors have yielded disappointing results in clinical, therapeutic trials. This is because optimal growth factor combinations, concentrations, release kinetics, and spatial presentations are unknown. Thus, there is a need to develop translatable technologies for precisely…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.