Ezeamama Lab

Research focus

NIH R01 · 2024

Vitamin D and Gut Microbiota and Dementia Risk in Older Adults with Chronic HIV infection and Demographically Matched Community Controls

The global burden of Alzheimer’s dementia and related disorders (ADRD) is growing in tandem with the demographic transition toward an aged society where older adults ≥65 years old that are more vulnerable to ADRD constitute a larger share of the general population. The fastest increase in ADRD and aging adults is occurring in sub-Saharan Africa where persons 50+ years old living with chronic HIV infection (OPH+) on combination antiretroviral therapy represent as much as 20% of older adults in some settings. OPH+ are at further risk of adverse cognitive outcomes and potentially ADRD due to HIV- and HIV-treatment-related biological and psychosocial risks such as gut-microbial dysbiosis,…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.