NIH R01 · 2025
Cellular origins and molecular mechanisms of arthrofibrosis
ABSTRACT Arthrofibrosis is a debilitating fibrotic joint disorder, which causes excessive scar tissue formation within the joint and surrounding soft tissues after injury and/or surgery leading to painful restriction of joint flexion and extension that persists despite rehabilitation. Damage to the joint resulting in chronic inflammation activates proliferation and differentiation of progenitor cells, also known as fibro-adipogenic progenitors, into highly specialized pro- fibrotic cells that deposit excessive amounts of disorganized collagen causing contraction. Estimated rates of arthrofibrosis induced by knee surgery, such as anterior cruciate ligament reconstruction or total knee…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.