NIH R01 · 2024
Mechanisms Regulating Neurotensin Secretion and Function
ABSTRACT Our multidisciplinary research team has been studying the function and effects of neurotensin (NT), a tridecapeptide localized to specialized enteroendocrine cells predominantly in the small bowel, for almost three decades. The most potent stimulus for NT release is ingestion of dietary fats. NT facilitates fatty acid (FA) absorption in the intestine, stimulates growth of cancers that have the high affinity NT receptor 1 (NTR1), and contributes to overall metabolism although its precise role in these processes has not been clearly delineated. Recent studies have identified a significant association of increased fasting pro-NT (a stable NT precursor fragment produced in equimolar…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.