NIH R01 · 2024
Hormonal Regulation of Mammalian Gene Expression
Nuclear receptors (NRs) influence development and physiology by controlling patterns of gene expression via ligand-directed chromatin modifications. The resultant induced epigenomic state mobilizes networks of genes to engender unique cell functions and physiology. This proposal extends on previous studies that elucidated the roles of the NRs PPARd and ERRa/g in context-specific transcriptional activities that reprogram skeletal muscle metabolism and physiology to increase endurance performance. A central focus of exercise physiology has been the functional association of induced transcriptional programs with changes in histone acetylation, including understanding how the activation of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.