NIH R01 · 2024
Role of pressure induced renal inflammation in salt-sensitive hypertension
ABSTRACT Hypertension is a leading cause of global mortality and is the primary modifiable risk factor for renal and cardiovascular disease. In 50% of patients with essential hypertension, blood pressure increases in response to salt. Despite this, the mechanisms underlying salt-sensitive hypertension remain poorly understood. Our studies in Dahl salt-sensitive (SS) rats have shown that proteinuria is indicative of the initiation of salt-sensitive hypertension, whereas renal inflammation is involved in the amplification of the disease. To date, the link between proteinuria and renal inflammation in salt-sensitive hypertension has not been elucidated, moreover the mechanisms by which renal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.