NIH R01 · 2025
Function and Regulation of Airway Mucin Glycosylation
PROJECT SUMMARY The lungs are exposed to billions of potentially harmful particles daily. Robust defense is crucial, but protection must cause minimal physiologic disruption. Accordingly, a thin and easily transported layer of mucus lines the airways in health. In asthma, mucus aggregates on airway surfaces and obstructs airflow, but this is not effectively treated with existing therapies. We seek to close this gap by building a better mechanistic understanding of how mucus function and dysfunction are mediated by the chief macromolecules in airway mucus--MUC5AC and MUC5B. Their importance is well-recognized through studies in humans and animal models. MUC5B is required for mucociliary…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.