Evankovich Lab

Research focus

NIH R01 · 2025

Indole Metabolites as Xenobiotic Danger signals in Acute Lung Injury

ABSTRACT This application is for an NHLBI R01 entitled “Indole Metabolites as Xenobiotic Danger Signals in Acute Lung Injury.” I am a physician in Pulmonary and Critical Care Medicine at the University of Pittsburgh, and I am building a research program focused on the studying the intersection of danger signals and host responses in epithelial cells in the pathogenesis of Acute Respiratory Distress Syndrome (ARDS). ARDS is an urgent public health problem characterized by severe inflammatory lung injury with impaired gas exchange, a high mortality risk (up to 40%), and long-term morbidity in survivors. Beyond supportive clinical care bundles that define the standard-of-care for ARDS, there…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.