NIH R01 · 2025
Targeting cell-to-cell communication to prevent bystander damage mediated by viral reservoirs
Abstract: “Targeting cell-to-cell communication to prevent bystander damage mediated by viral reservoirs.” Soon after primary infection, HIV enters the CNS and causes long-lasting cognitive and motor impairment in 30-60% of infected individuals, even in the current antiretroviral (ART) era. In the CNS, HIV remains latent in a small population of microglia/macrophages and a smaller population of astrocytes. Our human brain data indicate that long-term ART reduces the myeloid (microglia/macrophage) pool of viral reservoirs (up to 23 years on ART). However, long-term ART did not reduce the astrocyte-infected pool. Furthermore, chronic damage to uninfected cells was associated with glial viral…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.