NIH R01 · 2025
In vivo monitoring of tumor microenvironment regulation for macrophages
Hypoxia and macrophages drive tumor aggressiveness and treatment outcome leading to worse prognosis for breast cancer patients. Contrary to acute hypoxia where tissue homeostasis is vital for development and repair, chronic hypoxia observed in solid tumors stimulate unproductive angiogenesis by excessive vascular endothelial growth factor expression leading to dysfunctional vessels that perpetuate hypoxia and acidic extracellular pH; factors that limit effective perfusion of treatment modalities like chemotherapies and radiotherapies and promote tumor aggressiveness. Macrophages are intimately involved in regulating unproductive angiogenesis thru secretion of soluble factors that support…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.