NIH R01 · 2025
Mechanism of intestinal TET3-mediated DNA oxidation and transcriptional regulation
PROJECT SUMMARY DNA methylation dynamics in mammals are an integral component of the epigenetic regulatory machinery. Methylated DNA functions as a repressive mark for gene expression and essential for cell fate determination during embryonic development. In adult tissues, DNA methylation at specific genomic loci is essential for the maintenance of cellular identity and function. Changes of DNA methylation profiles in intestinal epithelial cells (IECs) were observed upon colonization by commensal microbiota. However, how environmental cues including the microbiota, enteric pathogens and chemical stressors affect DNA methylation patterns in the intestinal epithelia, remains largely unclear.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.