NIH R01 · 2024
Heritable immunization of the white-footed mouse reservoir of Lyme disease
Project Summary RFA-AI-19-037 The rising incidence of Lyme disease demands new strategies for prevention. Existing methods such as acaricides, deer reduction, landscaping, and personal protective clothing, are inherently short-term and must be regularly re-applied, maintained and worn. The Mice Against Ticks project seeks to develop a durable one-time intervention to disrupt the ecological cycle of Lyme disease transmission for many decades. The causative agent of Lyme disease B. burgdorferi is passed back and forth between ticks and their small animal hosts, which serve as zoonotic reservoirs of disease. The white-footed mouse P. leucopus is widely considered to be the most…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.