NIH R01 · 2024
The Role of Hippo-Yap1 Signaling in Germ-layer Specification
ABSTRACT Understanding diagnose, on signaling well-known for its essential activities promoting cell proliferation during development. suggest important roles of YAP as a cell-fate determinant in early embryogenesis. Accordingly, our ongoing studies using human Embryonic Stem Cells (hESCs) 2D- models of gastrulation reveals that YAP is essential for the correct specification of the three germ-layers. The YAP KO-derived human 2D-gastruloids display expanded mesoderm and endoderm layers (ME) and reduced ectoderm layer, compared to WT. NODAL signaling homeostasis is essential for normal gastrulation; active NODAL cues are needed for ME differentiation. However, efficient NODAL inhibition is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.