NIH R01 · 2024
Intra and Extra-Chromosomal Probes for Mutagenesis by Carcinogens
Project Summary/Abstract Human cancer genomes show a complex pattern of mutations that, upon computational deconvolution, resolves into a systematic series of over 80 “Mutational Signatures” (the pattern of mutations across all possible trinucleotide sequence contexts). Some signatures are common to many cancers (e.g., CGàTA in CpG sites) whereas others appear in single tumor types (e.g., signatures involving GCàTA mutations that are presumably associated with aflatoxin B1 (AFB1) exposure in hepatocellular carcinoma (HCC)). Current sequencing efforts sometimes provide hints, via examination of the details of mutational signatures, as to cancer mechanistic etiology. The first two Aims of the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.