NIH R01 · 2024
Circadian Control of Brain-peripheral Immune Response After Stroke
Circadian control of brain-peripheral immune response after stroke Aging and circadian rhythm are strong modulators of the immune system, and the immune response is a major contributor to stroke pathophysiology. But how aging and circadian rhythm interacts to influence immune response after stroke remains poorly understood. In this project, we will focus on the brain-to-cervical lymph node signaling pathway (Esposito et al, Nat Commun 2019). Because lymphatic drainage is regulated by circadian rhythm, and circadian rhythm is altered in aging, we hypothesize that this pathway may provide a novel integrating mechanism that connects these 3 major factors in stroke pathophysiology: immune…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.