NIH R01 · 2025
Sleep Disturbances During Cocaine Abstinence, Dopamine Adaptations, and Motivation for Cocaine
Project Summary/Abstract Cocaine use disorder is a chronic disease and currently no approved pharmacotherapies exist for its treatment. Among the greatest challenges in the treatment of cocaine use disorder is prevention of relapse to drug use. In rats, periods of abstinence following cocaine use intensifies seeking and motivation for drug, which has been associated with increased propensity for relapse. Although extensive evidence indicates that mesolimbic dopamine influences cocaine reinforcement, the involvement of dopamine in the regulation of sleep has received comparatively less attention. We recently demonstrated that the dopamine transporter governs diurnal fluctuations in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.