NIH R01 · 2025
Serotonergic modulation of aggressive and prosocial behaviors
Low frustration tolerance and excessive aggression are major causes of suffering across multiple psychiatric disorders. Although foundational work has revealed neural populations in the amygdala, hypothalamus, and brainstem that are necessary to trigger aggressive behavior, the upstream circuits that modulate this behavior depending on context are less understood. Furthermore, aggression is just one of multiple social behaviors, and it remains unclear how the brain facilitates flexible transitions between these behaviors. In this project, we aim to remedy these gaps in the literature by exploring the possible mechanistic links between aggression and its counterpart: prosocial, affiliative…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.