Escobar Sanabria Lab

Research focus

NIH R01 · 2024

Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinson’s Disease Using Real-Time Neural Control

PROJECT SUMMARY While much research has been dedicated to understanding the pathophysiology of Parkinson’s disease (PD), the neural dynamics underlying the manifestation of motor signs remain unclear. Studies over the past two decades have shown a correlation between the amplitude and incidence of beta band oscillations in the subthalamic nucleus (STN) and changes in bradykinesia and rigidity mediated by levodopa or deep brain stimulation (DBS) therapies. Yet, no study has conclusively or deductively demonstrated a causal link. A limitation to establishing causality is the lack of available neuromodulation tools capable of predictably and precisely controlling neural oscillatory activity in…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.