NIH R01 · 2024
Understanding and targeting mutant splicing factors in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal cancer that is resistant to currently available therapies. Notably, we discovered that PDACs are exquisitely susceptible to a range of therapies directed at RNA splicing. However, it is unknown how alterations in RNA splicing drive PDAC tumorigenesis or impact therapeutic responses. Thus, identification of the role of aberrant RNA splicing in PDAC tumorigenesis could reveal novel therapeutic targets for PDAC. Our long-term goal is to identify, design, and test novel mechanistic-based targeted therapies for highly aggressive tumors such as PDAC. The main objective of this proposal is to characterize the role of RNA…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.