NIH R01 · 2025
Cytoskeletal Interactions of Dystrophin
PROJECT SUMMARY/ABSTRACT The long-term objective of this project is to fully define the functions of dystrophin in striated muscle to understand how its absence or abnormality leads to the pathologies observed in Duchenne and Becker muscular dystrophies, and to inform on the potential for miniaturized dystrophins or utrophin to substitute for dystrophin in a therapeutic context. In the current project period, we generated a new line of transgenic mdx mice that expresses dystrophin lacking in vitro microtubule binding activity, but which surprisingly presented with a fully rescued cortical microtubule lattice. We also analyzed microtubule organization in existing lines of transgenic mdx mice…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.