NIH R01 · 2024
ABSTRACT Major depressive disorder (MDD) is a chronic, recurrent illness impacting 20.6% of the U.S. population, causing significant disability and an economic impact of $326.2 billion annually. One of the largest risk factors for depression chronicity and disability is inadequate antidepressant response, defined as less than a 50% improvement in depressive symptoms after starting antidepressant treatment. Antidepressants are recommended as a first-line depression treatment and taken by 70% of patients with depression. Inadequate antidepressant response is experienced by 50-60% of patients starting an antidepressant and is responsible for 47% of the economic impact and disability caused by…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.