NIH R01 · 2025
Examining the Persistence of Neurocognitive Benefits of Exercise
Project Summary/Abstract Physical activity (PA) is one of the most promising approaches for mitigating age-related cognitive decline and risk for dementia, yet few sufficiently powered randomized clinical trials (RCT) targeting brain health outcomes have been conducted. Further, little is known about the biological pathways and moderators of the brain response to exercise. To address these gaps, we have conducted a multi-site, supervised, dose-response (150min/wk of moderate-intensity; 225min/wk of moderate-intensity; 150min/wk of light intensity), aerobic exercise RCT with brain health outcomes as the primary endpoints in 648 cognitively normal adults between 65-80 years of age. This…
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