NIH R01 · 2025
Sialylated antibody defense against intracellular infections
Sialylated antibody defense against intracellular infections Abstract. Division of labor between humoral and cellular adaptive immune components for effective host defense is a foundational immunological tenet. Antibodies are thought to offer limited protection against intracellular pathogens since they cannot efficiently cross the plasma membrane to enter most cells, which may explain the prevalence of intracellular infections in fetuses and newborns given their dependence on vertically transferred maternal IgG for early life immunity. However, we recently demonstrated that pregnancy enables antibody-mediated protection against the prototypical intracellular pathogen Listeria monocytogenes…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.