NIH R01 · 2024
Extracellular Vesicles, Insulin Action and Exercise on Vascular Function in Type 2 Diabetes
PROJECT ABSTRACT Insulin resistance in the vasculature is often linked to obesity and type 2 diabetes (T2D). This occurs prior to metabolic derangement as evidenced by endothelial dysfunction that, in turn, contributes to the rises in blood pressure and glucose. However, the mechanism by which vascular dysfunction occurs throughout the progression from obesity to T2D is unknown. A better understanding of the mechanisms responsible for differences in vascular function between people with obesity and T2D compared to lean healthy controls can provide critical mechanistic understandings into disease progression as well as potentially identify novel therapeutic targets. Extracellular vesicles…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.