NIH R01 · 2025
Pathogenic mechanisms of adult hearing loss caused by Zfp719 mutations
Project Description Hearing loss is the most prevalent sensory deficit in humans. Half of all cases of early onset hearing loss in developed countries have a genetic etiology, with single gene mutations in over 100 different loci identified so far. Mutations in the majority of these genes result in nonsyndromic sensorineural hearing loss, where abnormal inner ear function is the only diagnostic feature. In comparison to children, the genetic causes of hearing loss in adults are less well understood. Approximately, 80% of hearing loss cases are diagnosed after the second decade of life and yet, adults are rarely tested for genetic mutations as a possible cause of their condition. To help…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.