Epplein Lab

Duke University

PUBLIC HEALTH & PREV MEDICINE

Durham · United States

NIH-funded
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NIH R01 · 2025

Delineating the underlying reasons for the racial disparity in gastric cancer incidence in the United States

In the United States, gastric cancer is a particularly fatal disease (survival rate of approximately 32% at 5 years) as it is generally asymptomatic until late-stage, when treatment is no longer effective. Each year in the US, 26,000 people are diagnosed with gastric cancer, and over 10,000 people die of the disease. However, gastric cancer is a preventable disease, as the predominant cause of gastric cancer is infection with the common bacterium, Helicobacter pylori (H. pylori), for which successful eradication significantly reduces the risk of developing gastric cancer. H. pylori, which greatly varies in prevalence among different populations within the US, is the world’s single leading…

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