NIH R01 · 2024
The effects of cART and HIV-1 infection on neural circuitry
ABSTRACT A significant proportion of individuals receiving antiretroviral therapy (ART) for HIV-1 infection develop cognitive deficits. This may be due solely to the HIV-1 infection; however, this may also indicate that prolonged ART itself may contribute to the impairments, particularly in the context of HIV-1 infection. The latter possibility is of particular concern given that a growing number of uninfected individuals use antiretrovirals (ARVs) as pre- exposure prophylaxis (PrEP). The brain circuitry that may be affected by prolonged treatment with ARVs or by ARVs in the context of HIV-1 infection is unknown. We propose to apply our recently developed array of new tools for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.