NIH R01 · 2024
ABSTRACT New neurons in the adult human and animal hippocampus have been implicated in several cognitive functions. These functions are profoundly impaired by the loss or insufficient production of new neurons. Neurons are produced after a prolonged series of transitions including the activation, proliferation, elimination, and differentiation of neural stem cells and their progeny. Competing hypotheses have been proposed to describe how these steps are executed. These hypotheses imply divergent, sometimes contradicting, blueprints of the transitions from stem cells to neurons, as well as different outcomes when these blueprints are perturbed by aging or disease. Alzheimer's disease (AD)…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.