NIH R01 · 2025
Material Stiffness Directs Oral Cancer Migration
Project Summary Oral squamous cell carcinoma (OSCC) is the sixth most common epithelial cancer worldwide with 50,000 new cases/year in US. Despite being less frequent, survival rates are relative lower. Clinically, OSCC presents as a necrotic lesion with stiffened borders; surgical resection requires significant tissue loss up to 2 cm surround the lesion, owing to the fact that these tumors are poorly margined and require significant resection to ensure all metastatic disease is removed. Even with aggressive surgical approaches, significant morbidity and mortality is associated with OSCC, and this dramatically reduces patient quality of life. While stiffened borders are a hallmark of the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.