NIH R01 · 2024
HIV-1 Preintegration Trafficking and Nuclear Localization
PROJECT SUMMARY This longstanding NIH grant over its lifetime has made seminal discoveries on the mechanisms of intranuclear HIV-1 trafficking and nuclear localization. In prior funding cycles, we determined that the nuclear pore complex protein nucleoporin 153 interacted with the viral protein capsid to affect the translocation of incoming viral replication complexes into the cell nucleus and sites of viral DNA integration in the human genome. We also first identified the cellular alternate polyadenylation protein cleavage and polyadenylation specificity factor 6 (CPSF6) as a direct binding partner of the viral capsid and revealed an important role for this interaction in integration of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.