NIH R01 · 2024
Development of new tags for RNA visualization
PROJECT SUMMARY RNA plays numerous roles in biology. In addition to its canonical role in the central dogma as an intermediary between DNA genomes and protein products of translation, a myriad of roles have been described for this molecule, including gene silencing (siRNA), regulation of translation (bacterial riboswitches), and the translation machinery itself (rRNA). Despite the importance of these roles in biology, tools for imaging RNA are not as robust as the suite of fluorescent proteins that exist for readout of protein machinery. This project seeks to address this need by developing new fluorescent aptamer tags for RNA visualization. This strategy has enjoyed considerable success,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.