NIH R01 · 2025
C type Lectin Pathway Regulates Macrophage Immune Metabolism in Mtb-Infected Lung
ABSTRACT Pathogen recognition receptors (PRR) pathways are critical for integrating the complex microbial stimuli encountered by innate immune cells to direct the appropriate host response. Among these PRR systems, the C type lectin (CLR) responses are the least understood. CLRs are abundantly expressed by many myeloid cell populations and perform a growing list of roles in recognition, internalization, and inflammatory response regulation following host exposure to microbial insult. These recognition pathways are further complicated in the setting of co-infections such as HIV where conflicting or synergist signaling can drive dysfunctional outcomes including inflammation. Understanding how…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.