NIH R01 · 2025
Neuronal responses to chronic demyelination
PROJECT SUMMARY Oligodendrocytes are a highly specialized type of glial cell that myelinates axons of the vertebrate CNS, both promoting rapid transmission of nerve impulses via saltatory conduction and providing metabolic and trophic support for the axons. A widely held consensus view in the field holds that the loss of this oligodendrocyte support (as seen in demyelinating conditions such as multiple sclerosis) directly contributes to axonal loss and cumulative disability. Nevertheless, direct experimental evidence for oligodendrocyte support being required for axonal survival is largely lacking. In addition, there is remarkably little information available on how neurons respond to a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.