NIH R01 · 2024
Frontotemporal dementia in rhesus macaques
ABSTRACT Frontotemporal dementia (FTD) is the most frequent dementia in patients under 60 years old. Mutations in MAPT (the gene encoding for the Tau protein), including the autosomal dominant R406W missense point mutation, have been linked to FTD. Current evidence supports the concept that FTD neurodegeneration starts decades before symptom onset, yet genetic FTD studies in young adults or minors are seldomly done, due to the challenges of disclosing genetic condition and the burden of long-term testing. Defining when the pathological processes begin will be critical to administer neuroprotective therapies before substantial neuronal loss and, therefore, to prevent FTD onset. At the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.