NIH R01 · 2025
Functional Role of HIF-PHDs in ARDS
PROJECT SUMMARY This application aims to investigate the regulation of hypoxia-inducible factor HIF1A by HIF- prolylhydroxyalses (PHDs) during acute respiratory distress syndrome (ARDS). ARDS is an extreme inflammatory response of the lungs triggered by injury or infection. In surgical patients, ARDS can occur after major surgery and causes dramatic increases in morbidity and mortality. Moreover, ARDS profoundly impacts patients with infections or sepsis, including the recent COVID-19 pandemic. However, only a minor percentage of patients who undergo major surgery or who have lung infections go on to develop ARDS. Therefore, we hypothesized that endogenous adaptive responses exist to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.