NIH R01 · 2025
The role of oral microbially induced exosomes in Alzheimer's disease pathogenesis
Alzheimer’s disease and related dementia (ADRD) affect 50 million people worldwide with no effective cure. Currently, more than 6.2 million Americans aged 65 years and older are suffering from AD, with a projection of that number doubling in 2060. A role for infectious disease in the pathogenesis of AD has long been proposed with viruses such as HSV and, more recently gingipains of the oral pathogen Porphyromonas gingivalis (Pg), detected in the brains of AD patients postmortem. There is a strong epidemiologic association between periodontitis (PD) and AD but how these two diseases intersect, and whether it is at the level of causation is unclear. Recent evidence shows a role for Pg and its…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.