NIH R01 · 2025
Metabolic pathways in cardiac physiology and heart failure
PROJECT SUMMARY - ABSTRACT Central to the development of HF are derangements in cardiac metabolism and a shift in fuel utilization. A recent clinical report of arterial/coronary sinus metabolomics identified glutamine as the most abundant metabolite released from the failing heart (i.e., production of glutamine rather than catabolism). Glutamine metabolism is directly linked to bioenergetics, mitochondrial function, redox state, nitrogen balance, and the biosynthesis of nucleic acids and proteins. Furthermore, we’ve recently shown that glutaminolysis is necessary for myofibroblast differentiation and persistence, that underlies cardiac fibrosis. Coupled together, these findings directed us…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.