NIH R01 · 2025
Dissecting host-virus interactions underlying motor neuron toxicity in Acute Flaccid Myelitis
Project Summary Acute flaccid myelitis (AFM) is a debilitating polio-like paralytic illness of children caused by enterovirus infection. There have been several international outbreaks of AFM in the past decade associated with Enterovirus D68 (EV-D68) and Enterovirus A71 (EV-A71), representing a significant public health threat. AFM is characterized by viral invasion of the spinal cord with subsequent infection of motor neurons followed by their dysfunction and death, however the mechanisms leading to motor neuron injury are not known. Interestingly, EV-A71 is associated with a spontaneously reversible form of AFM, whereas the paralysis resulting from EV-D68 infection is typically…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.